Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology
Extracellular ATP is a critical signaling molecule that is found in a wide range of concentrations across cellular environments. The family of nonselective cation channels that sense extracellular ATP, termed P2X receptors (P2XRs), is composed of seven subtypes (P2X1-P2X7) that assemble as functiona...
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