A Novel Co-Crystal of Bexarotene and Ligustrazine Improves Pharmacokinetics and Tissue Distribution of Bexarotene in SD Rats

• Main Authors: Shuyue Ren (Author), Lingtai Jiao (Author), Shiying Yang (Author), Li Zhang (Author), Junke Song (Author), Haoying Yu (Author), Jingrong Wang (Author), Tingting Lv (Author), Lan Sun (Author), Yang Lu (Author), Guanhua Du (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bexarotene (BEX), a specific retinoic acid X receptor (RXR) agonist granted by Food and Drug Administration (FDA) approval for the clinical treatment of T cell lymphoma, has now been found to exert pharmacological effects in the nervous system, with low bioavailability and poor cerebral distribution...