Improving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype

• Main Authors: Mira Malcov (Author), Veronica Gold (Author), Sagit Peleg (Author), Tsvia Frumkin (Author), Foad Azem (Author), Ami Amit (Author), Dalit Ben-Yosef (Author), Yuval Yaron (Author), Adi Reches (Author), Shimi Barda (Author), Sandra E. Kleiman (Author), Leah Yogev (Author), Ron Hauser (Author)
• Format: Book
• Published: BMC, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier's one. Methods A panel of 4-9 informative polymorphic markers, flanking...