Increase in the Complement Activation Product C4d and the Terminal Complement Complex sC5b-9 Is Associated with Disease Severity and a Fatal Outcome in Necrotizing Soft-Tissue Infection

• Main Authors: Morten Hedetoft (Author), Martin Bruun Madsen (Author), Cecilie Bo Hansen (Author), Ole Hyldegaard (Author), Peter Garred (Author)
• Formato: Livro
• Publicado em: Karger Publishers, 2021-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The hyperinflammatory burden is immense in necrotizing soft-tissue infection (NSTI). The complement system is a key during the innate immune response and may be a promising target to reduce the inflammatory response, potentially improving the clinical outcome. However, complement activation and its...