Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation

• Main Authors: Silvia Mandillo (Author), Ines Heise (Author), Luciana Garbugino (Author), Glauco P. Tocchini-Valentini (Author), Alessandro Giuliani (Author), Sara Wells (Author), Patrick M. Nolan (Author)
• Format: Book
• Published: The Company of Biologists, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deficits in motor function are debilitating features in disorders affecting neurological, neuromuscular and musculoskeletal systems. Although these disorders can vary greatly with respect to age of onset, symptomatic presentation, rate of progression and severity, the study of these disease models i...