Inhibition of Autophagy Enhances Sunitinib-Induced Cytotoxicity in Rat Pheochromocytoma PC12 cells

• Main Authors: Tatsuhiko Ikeda (Author), Kiyo-aki Ishii (Author), Yuria Saito (Author), Masahiro Miura (Author), Aoi Otagiri (Author), Yasushi Kawakami (Author), Hitoshi Shimano (Author), Hisato Hara (Author), Kazuhiro Takekoshi (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sunitinib is an oral multitargeted receptor tyrosine kinase inhibitor with antiangiogenic and antitumor activity that mainly targets vascular endothelial growth factor receptors, and recently, it has been shown to be an active agent for the treatment of malignant pheochromocytomas. Previously, we de...