Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

• Main Authors: Ekaterina Savchenko (Author), Yajuvinder Singh (Author), Henna Konttinen (Author), Katarina Lejavova (Author), Laura Mediavilla Santos (Author), Alexandra Grubman (Author), Virve Kärkkäinen (Author), Velta Keksa-Goldsteine (Author), Nikolay Naumenko (Author), Pasi Tavi (Author), Anthony R. White (Author), Tarja Malm (Author), Jari Koistinaho (Author), Katja M. Kanninen (Author)
• Format: Book
• Published: The Company of Biologists, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The neuronal ceroid lipofuscinoses (NCLs) are the...