Targeting mechanotransduction at the transcriptional level: YAP and BRD4 are novel therapeutic targets for the reversal of liver fibrosis

• Main Authors: Altynbek Zhubanchaliyev (Author), Aibar Temirbekuly (Author), Kuralay Kongrtay (Author), Leah Corvin Wanshura (Author), Jeannette Kunz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver fibrosis is the result of a deregulated wound healing process characterized by the excessive deposition of extracellular matrix (ECM). Hepatic stellate cells (HSCs), which are activated in response to liver injury, are the major source of ECM and drive the wound healing process. However, chron...