Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

• Main Authors: Minsung Kang (Author), Chijung Kim (Author), Jiyeon Leem (Author), Ye-hyun Kim (Author), Young-ju Kwon (Author), Yi Na Yoon (Author), Chong Hak Chae (Author), Jiyeon Ahn (Author), Kwan-Young Jung (Author), Jeong Su Oh (Author), Jae-Sung Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although microtubule-associated serine/threonine kinase-like (MASTL) is a promising target for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor efficacy have not been reported. Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2...