Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

• Autors principals: Minsung Kang (Autor), Chijung Kim (Autor), Jiyeon Leem (Autor), Ye-hyun Kim (Autor), Young-ju Kwon (Autor), Yi Na Yoon (Autor), Chong Hak Chae (Autor), Jiyeon Ahn (Autor), Kwan-Young Jung (Autor), Jeong Su Oh (Autor), Jae-Sung Kim (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2021-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Although microtubule-associated serine/threonine kinase-like (MASTL) is a promising target for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor efficacy have not been reported. Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2...