Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor-κ B Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors

• Main Authors: Hironori Takei (Author), Yuichiro Baba (Author), Akinori Hisatsune (Author), Hiroshi Katsuki (Author), Takeshi Miyata (Author), Kazumi Yokomizo (Author), Yoichiro Isohama (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was designed to examine the glucocorticoid-like inhibitory effect of glycyrrhizin (GL) on interleukin (IL)-8 production in A549 lung epithelial cells. GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-α -and IL-1β -induced IL-8 production, mRNA expression, and...