Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy

• Main Authors: Katharina Busch (Author), Melanie Kny (Author), Nora Huang (Author), Tilman E. Klassert (Author), Magdalena Stock (Author), Alexander Hahn (Author), Sebastian Graeger (Author), Mihail Todiras (Author), Sibylle Schmidt (Author), Bishwas Chamling (Author), Michael Willenbrock (Author), Stefan Groß (Author), Doreen Biedenweg (Author), Arnd Heuser (Author), Claus Scheidereit (Author), Christian Butter (Author), Stephan B. Felix (Author), Oliver Otto (Author), Friedrich C. Luft (Author), Hortense Slevogt (Author), Jens Fielitz (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome, compromises cardiac function. Whether or not deleting Nlrp3 would prevent cardiac atrophy and improve diastolic cardiac...