Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator

• Главные авторы: Kun Wang (Автор), Xueting Yao (Автор), Miao Zhang (Автор), Dongyang Liu (Автор), Yuying Gao (Автор), Srikumar Sahasranaman (Автор), Ying C. Ou (Автор)
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• Опубликовано: Wiley, 2021-05-01T00:00:00Z.
• Предметы: article
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Abstract A physiologically based pharmacokinetic (PBPK) model was developed to evaluate and predict (1) the effect of concomitant cytochrome P450 3A (CYP3A) inhibitors or inducers on the exposures of zanubrutinib, (2) the effect of zanubrutinib on the exposures of CYP3A4, CYP2C8, and CYP2B6 substrat...