Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator

• Main Authors: Kun Wang (Author), Xueting Yao (Author), Miao Zhang (Author), Dongyang Liu (Author), Yuying Gao (Author), Srikumar Sahasranaman (Author), Ying C. Ou (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A physiologically based pharmacokinetic (PBPK) model was developed to evaluate and predict (1) the effect of concomitant cytochrome P450 3A (CYP3A) inhibitors or inducers on the exposures of zanubrutinib, (2) the effect of zanubrutinib on the exposures of CYP3A4, CYP2C8, and CYP2B6 substrat...