Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila

• Egile Nagusiak: Stephanie M. Pütz (Egilea), Jette Kram (Egilea), Elisa Rauh (Egilea), Sophie Kaiser (Egilea), Romy Toews (Egilea), Yi Lueningschroer-Wang (Egilea), Dirk Rieger (Egilea), Thomas Raabe (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2021-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Parkinson's disease (PD) provokes bradykinesia, resting tremor, rigidity and postural instability, and also non-motor symptoms such as depression, anxiety, sleep and cognitive impairments. Similar phenotypes can be induced in Drosophila melanogaster through modification of PD-relevant genes or...