Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila

• Main Authors: Stephanie M. Pütz (Author), Jette Kram (Author), Elisa Rauh (Author), Sophie Kaiser (Author), Romy Toews (Author), Yi Lueningschroer-Wang (Author), Dirk Rieger (Author), Thomas Raabe (Author)
• Format: Book
• Published: The Company of Biologists, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) provokes bradykinesia, resting tremor, rigidity and postural instability, and also non-motor symptoms such as depression, anxiety, sleep and cognitive impairments. Similar phenotypes can be induced in Drosophila melanogaster through modification of PD-relevant genes or...