Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1
The human proinsulin gene (INS) contains a thymine-to-adenine variant (rs689) located in the 3' splice site (3' ss) recognition motif of the first intron. The adenine at rs689 is strongly associated with type 1 diabetes. By weakening the polypyrimidine tract, the adenine allele reduces the...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2019-06-01T00:00:00Z.
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