Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma

Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies. The mutated Gαq/11 are perceived as oncogenic drivers in the vast majority of uveal melanoma (UM) cases, making directly targeting Gαq/11 to be a promising strategy for combating UM. He...

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Main Authors: Yang Ge (Author), Jun-Jie Deng (Author), Jianzheng Zhu (Author), Lu Liu (Author), Shumin Ouyang (Author), Zhendong Song (Author), Xiaolei Zhang (Author), Xiao-Feng Xiong (Author)
Format: Book
Published: Elsevier, 2022-08-01T00:00:00Z.
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