Host cell protein quantification workflow using optimized standards combined with data-independent acquisition mass spectrometry

Monitoring of host cell proteins (HCPs) during the manufacturing of monoclonal antibodies (mAb) has become a critical requirement to provide effective and safe drug products. Enzyme-linked immunosorbent assays are still the gold standard methods for the quantification of protein impurities. However,...

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Main Authors: Steve Hessmann (Author), Cyrille Chery (Author), Anne-Sophie Sikora (Author), Annick Gervais (Author), Christine Carapito (Author)
Format: Book
Published: Elsevier, 2023-05-01T00:00:00Z.
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