p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy

• Main Authors: Darko Bosnakovski (Author), Micah D. Gearhart (Author), Erik A. Toso (Author), Olivia O. Recht (Author), Anja Cucak (Author), Abhinav K. Jain (Author), Michelle C. Barton (Author), Michael Kyba (Author)
• Format: Book
• Published: The Company of Biologists, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant myopathy caused by mutations that disrupt repression of the normally silent DUX4 gene, which encodes a transcription factor that has been shown to interfere with myogenesis when misexpressed at very low levels in myoblasts and t...