p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy

• Główni autorzy: Darko Bosnakovski (Autor), Micah D. Gearhart (Autor), Erik A. Toso (Autor), Olivia O. Recht (Autor), Anja Cucak (Autor), Abhinav K. Jain (Autor), Michelle C. Barton (Autor), Michael Kyba (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2017-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant myopathy caused by mutations that disrupt repression of the normally silent DUX4 gene, which encodes a transcription factor that has been shown to interfere with myogenesis when misexpressed at very low levels in myoblasts and t...