Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response

• Main Authors: Zhipeng Zhao (Author), Lu Feng (Author), Xuerun Peng (Author), Tingnan Ma (Author), Rongsheng Tong (Author), Lei Zhong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic alterations are implicated in tumour immune evasion and immune checkpoint blockade (ICB) resistance. SET domain bifurcated histone methyltransferase 1 (SETDB1) is a histone lysine methyltransferase that catalyses histone H3K9 di- and tri-methylation on euchromatin, and growing evidence in...