Induction of long-term tolerance to a specific antigen using anti-CD3 lipid nanoparticles following gene therapy

• Main Authors: Chun-Yu Chen (Author), Amber Vander Kooi (Author), Alex Cavedon (Author), Xiaohe Cai (Author), Jonathan Hoggatt (Author), Paolo G.V. Martini (Author), Carol H. Miao (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of factor VIII (FVIII) inhibitors is a serious complication in the treatment of hemophilia A (HemA) patients. In clinical trials, anti-CD3 antibody therapy effectively modulates the immune response of allograft rejection or autoimmune diseases without eliciting major adverse effects. In...