Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation

• Main Authors: Jiří Řehulka (Author), Michal Jurášek (Author), Pavel Dráber (Author), Aleksandra Ivanová (Author), Soňa Gurská (Author), Kateřina Ječmeňová (Author), Olena Mokshyna (Author), Marián Hajdúch (Author), Pavel Polishchuk (Author), Pavel B. Drašar (Author), Petr Džubák (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction, focusing on structural modifications within the aromatic bridge connecting two estradiol moiet...