Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

• Main Authors: Jung-Taek Kang (Author), Bumrae Cho (Author), Junghyun Ryu (Author), Caitlin Ray (Author), Eun-Jin Lee (Author), Yun-Jin Yun (Author), SunMi Ahn (Author), JinSeok Lee (Author), Dal-Young Ji (Author), Nathaniel Jue (Author), Sherrie Clark-Deener (Author), Kiho Lee (Author), Kwang-Wook Park (Author)
• Format: Book
• Published: BMC, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstracts Background Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study,...