A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation

• Main Authors: Atsuhiro Kanda (Author), Erdal Tan Ishizuka (Author), Atsushi Shibata (Author), Takahiro Matsumoto (Author), Hidekazu Toyofuku (Author), Kousuke Noda (Author), Kenichi Namba (Author), Susumu Ishida (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to the (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling. Here we revealed significant upregulation of prorenin...