Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

• Main Authors: Jayesh A. Dhanani (Author), Suzanne L. Parker (Author), Jeffrey Lipman (Author), Steven C. Wallis (Author), Jeremy Cohen (Author), John Fraser (Author), Adrian Barnett (Author), Michelle Chew (Author), Jason A. Roberts (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into mi...