A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

• Main Authors: Fang Bai (Author), Xiaoping Pi (Author), Ping Li (Author), Pingzheng Zhou (Author), Huaiyu Yang (Author), Xicheng Wang (Author), Min Li (Author), Zhaobing Gao (Author), Hualiang Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ion channels are important therapeutic targets, and their pharmacology is becoming increasingly important. However, knowledge of the mechanism of interaction of the activators and ion channels is still limited due to the complexity of the mechanisms. A statistical thermodynamic model has been develo...