Cardiac Sodium/Hydrogen Exchanger (NHE11) as a Novel Potential Target for SGLT2i in Heart Failure: A Preliminary Study

• Main Authors: Lorena Pérez-Carrillo (Author), Alana Aragón-Herrera (Author), Isaac Giménez-Escamilla (Author), Marta Delgado-Arija (Author), María García-Manzanares (Author), Laura Anido-Varela (Author), Francisca Lago (Author), Luis Martínez-Dolz (Author), Manuel Portolés (Author), Estefanía Tarazón (Author), Esther Roselló-Lletí (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the reduction of cardiovascular events, including the risk of death, associated with sodium/glucose cotransporter 2 inhibitors (SGLT2i), their basic action remains unclear. Sodium/hydrogen exchanger (NHE) has been proposed as the mechanism of action, but there are controversies related to it...