Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding

• Egile Nagusiak: Matthias Van der Veken (Egilea), Joachim Brouwers (Egilea), Agustos Cetin Ozbey (Egilea), Kenichi Umehara (Egilea), Cordula Stillhart (Egilea), Noël Knops (Egilea), Patrick Augustijns (Egilea), Neil John Parrott (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically based pharmacokinetic (PBPK) modelling has provided insights into tacrolimus disposition in adults but has limited applicatio...