Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome

• Main Authors: Jana K. Shirey-Rice (Author), Rebecca Klar (Author), Hugh M. Fentress (Author), Sarah N. Redmon (Author), Tiffany R. Sabb (Author), Jessica J. Krueger (Author), Nathan M. Wallace (Author), Martin Appalsamy (Author), Charlene Finney (Author), Suzanna Lonce (Author), André Diedrich (Author), Maureen K. Hahn (Author)
• Format: Book
• Published: The Company of Biologists, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Postural orthostatic tachycardia syndrome (POTS) is a common autonomic disorder of largely unknown etiology that presents with sustained tachycardia on standing, syncope and elevated norepinephrine spillover. Some individuals with POTS experience anxiety, depression and cognitive dysfunction...