Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics

• Main Authors: Eva González-Iglesias (Author), Dolores Ochoa (Author), Marcos Navares-Gómez (Author), Pablo Zubiaur (Author), Marina Aldama (Author), Tamara de la Torre (Author), Marta de los Ríos-Rodríguez (Author), Paula Soria-Chacartegui (Author), Andrea Rodríguez-Lopez (Author), Francisco Abad-Santos (Author), Jesús Novalbos (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionEzetimibe inhibits cholesterol uptake by modulation of intestinal sterol absorption. Currently, although some studies have shown alterations in ezetimibe levels caused by alterations in the ABCG5, ABCG8, NPC1L1 or UGT1A1 genes, there are no pharmacogenetic guidelines to confirm these bio...