Variability in dengue titer estimates from plaque reduction neutralization tests poses a challenge to epidemiological studies and vaccine development.

• Main Authors: Henrik Salje (Author), Isabel Rodríguez-Barraquer (Author), Kaitlin Rainwater-Lovett (Author), Ananda Nisalak (Author), Butsaya Thaisomboonsuk (Author), Stephen J Thomas (Author), Stefan Fernandez (Author), Richard G Jarman (Author), In-Kyu Yoon (Author), Derek A T Cummings (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Accurate determination of neutralization antibody titers supports epidemiological studies of dengue virus transmission and vaccine trials. Neutralization titers measured using the plaque reduction neutralization test (PRNT) are believed to provide a key measure of immunity to dengue virus...