Variability in dengue titer estimates from plaque reduction neutralization tests poses a challenge to epidemiological studies and vaccine development.

• Egile Nagusiak: Henrik Salje (Egilea), Isabel Rodríguez-Barraquer (Egilea), Kaitlin Rainwater-Lovett (Egilea), Ananda Nisalak (Egilea), Butsaya Thaisomboonsuk (Egilea), Stephen J Thomas (Egilea), Stefan Fernandez (Egilea), Richard G Jarman (Egilea), In-Kyu Yoon (Egilea), Derek A T Cummings (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2014-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

BACKGROUND:Accurate determination of neutralization antibody titers supports epidemiological studies of dengue virus transmission and vaccine trials. Neutralization titers measured using the plaque reduction neutralization test (PRNT) are believed to provide a key measure of immunity to dengue virus...