Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy

• Main Authors: P. Smyth (Author), L. Ferguson (Author), J. F. Burrows (Author), R. E. Burden (Author), S. R. Tracey (Author), Ú. M. Herron (Author), M. Kovaleva (Author), R. Williams (Author), A. J. Porter (Author), D. B. Longley (Author), C. J. Barelle (Author), C. J. Scott (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant activity of the cysteine protease Cathepsin S (CTSS) has been implicated across a wide range of pathologies. Notably in cancer, CTSS has been shown to promote tumour progression, primarily through facilitating invasion and migration of tumour cells and augmenting angiogenesis. Whilst an att...