Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke

• Main Authors: Emma Martínez-Alonso (Author), Alejandro Escobar-Peso (Author), Maria I. Ayuso (Author), Rafael Gonzalo-Gobernado (Author), Mourad Chioua (Author), Juan J. Montoya (Author), Joan Montaner (Author), Israel Fernández (Author), José Marco-Contelles (Author), Alberto Alcázar (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nitrones have a well-recognized capacity as spin-traps and are considered powerful free radical scavengers, which are two important issues in hypoxia-induced oxidative stress and cell death in brain ischemia. Consequently, nitrones have been proposed as therapeutic agents in acute ischemic stroke (A...