Antimicrobial action of the cyclic peptide bactenecin on Burkholderia pseudomallei correlates with efficient membrane permeabilization.

• Main Authors: Kanjana Madhongsa (Author), Supaluk Pasan (Author), Onanong Phophetleb (Author), Sawinee Nasompag (Author), Sompong Thammasirirak (Author), Sakda Daduang (Author), Suwimol Taweechaisupapong (Author), Andrei L Lomize (Author), Rina Patramanon (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Burkholderia pseudomallei is a category B agent that causes Melioidosis, an acute and chronic disease with septicemia. The current treatment regimen is a heavy dose of antibiotics such as ceftazidime (CAZ); however, the risk of a relapse is possible. Peptide antibiotics are an alternative to classic...