Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases

• Main Authors: Chi Lui Chan (Author), Yilu Sun (Author), Xiaowen Mao (Author), Hansen Chen (Author), Jia Zhao (Author), Jianhui Rong (Author)
• Format: Book
• Published: Compuscript Ltd, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemi...