Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003

• Үндсэн зохиолчид: Yuhan Liu (Зохиогч), Ruixiao Wang (Зохиогч), Ru Huang (Зохиогч), Beata Rutz (Зохиогч), Anna Ciotkowska (Зохиогч), Alexander Tamalunas (Зохиогч), Sheng Hu (Зохиогч), Moritz Trieb (Зохиогч), Raphaela Waidelich (Зохиогч), Frank Strittmatter (Зохиогч), Christian G. Stief (Зохиогч), Martin Hennenberg (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Background: NUAKs promote myosin light chain phosphorlyation, actin organization, proliferation and suppression of cell death in non-muscle cells, which are critical for smooth muscle contraction and growth. In benign prostatic hyperplasia (BPH), contraction and growth in the prostate drive urethral...