Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003

• Main Authors: Yuhan Liu (Author), Ruixiao Wang (Author), Ru Huang (Author), Beata Rutz (Author), Anna Ciotkowska (Author), Alexander Tamalunas (Author), Sheng Hu (Author), Moritz Trieb (Author), Raphaela Waidelich (Author), Frank Strittmatter (Author), Christian G. Stief (Author), Martin Hennenberg (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: NUAKs promote myosin light chain phosphorlyation, actin organization, proliferation and suppression of cell death in non-muscle cells, which are critical for smooth muscle contraction and growth. In benign prostatic hyperplasia (BPH), contraction and growth in the prostate drive urethral...