Pulmonary Safety Profile of Esc Peptides and Esc-Peptide-Loaded Poly(lactide-co-glycolide) Nanoparticles: A Promising Therapeutic Approach for Local Treatment of Lung Infectious Diseases

• Main Authors: Floriana Cappiello (Author), Bruno Casciaro (Author), Maria Rosa Loffredo (Author), Elena Puglisi (Author), Qiao Lin (Author), Dandan Yang (Author), Gemma Conte (Author), Ivana d'Angelo (Author), Francesca Ungaro (Author), Loretta Ferrera (Author), Raffaella Barbieri (Author), Laura Cresti (Author), Alessandro Pini (Author), Yuanpu Peter Di (Author), Maria Luisa Mangoni (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years, we have discovered Esc(1-21) and its diastereomer (Esc peptides) as valuable candidates for the treatment of Pseudomonas lung infection, especially in patients with cystic fibrosis (CF). Furthermore, engineered poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) were revealed to b...