Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids

• Main Authors: Gang Yang (Author), Yaping Zhao (Author), Nianping Feng (Author), Yongtai Zhang (Author), Ying Liu (Author), Beilei Dang (Author)
• Format: Book
• Published: Elsevier, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study was to improve the dissolution and bioavailability of silymarin (SM). Solid dispersions (SDs) were prepared using solution-enhanced dispersion by supercritical fluids (SEDS) and evaluated in vitro and in vivo, compared with pure SM powder. The particle sizes, stability, a...