Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay

• Główni autorzy: Byeong ill Lee (Autor), Seo-jin Park (Autor), Yuri Park (Autor), Seok-Ho Shin (Autor), Jang-mi Choi (Autor), Min-jae Park (Autor), Jeong-hyeon Lim (Autor), Sun Young Kim (Autor), Hyangsook Lee (Autor), Young G. Shin (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-01-01T00:00:00Z.
• Hasła przedmiotowe: article
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Antibody-drug conjugate (ADC) linkers play an important role in determining the safety and efficacy of ADC. The Ortho Hydroxy-Protected Aryl Sulfate (OHPAS) linker is a newly developed linker in the form of a di-aryl sulfate structure consisting of phenolic payload and self-immolative group (SIG). I...