Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo.

• Main Authors: Andrezza C Chagas (Author), Peter McPhie (Author), Hong San (Author), David Narum (Author), Karine Reiter (Author), Fuyuki Tokomasu (Author), Fabio A Brayner (Author), Luiz C Alves (Author), José M C Ribeiro (Author), Eric Calvo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to efficient blood feeding. Here we report the first inhibitor of collagen-induced platelet aggregation derived from the salivary glands of a black fly...