ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy

ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy

Generalized arterial calcification of infancy (GACI) is a rare, life-threatening disorder caused by loss-of-function mutations in the gene encoding ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), which normally hydrolyzes extracellular ATP into AMP and pyrophosphate (PPi). The disease is...

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Main Authors: Tayeba Khan (Author), Kerstin W. Sinkevicius (Author), Sylvia Vong (Author), Arlen Avakian (Author), Markley C. Leavitt (Author), Hunter Malanson (Author), Andre Marozsan (Author), Kim L. Askew (Author)
Format: Book
Published: The Company of Biologists, 2018-10-01T00:00:00Z.
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