ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy

• Asıl Yazarlar: Tayeba Khan (Yazar), Kerstin W. Sinkevicius (Yazar), Sylvia Vong (Yazar), Arlen Avakian (Yazar), Markley C. Leavitt (Yazar), Hunter Malanson (Yazar), Andre Marozsan (Yazar), Kim L. Askew (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2018-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Generalized arterial calcification of infancy (GACI) is a rare, life-threatening disorder caused by loss-of-function mutations in the gene encoding ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), which normally hydrolyzes extracellular ATP into AMP and pyrophosphate (PPi). The disease is...