A Guide to PIN1 Function and Mutations Across Cancers

• Главные авторы: Maguie El Boustani (Автор), Lucia De Stefano (Автор), Isabella Caligiuri (Автор), Nayla Mouawad (Автор), Carlotta Granchi (Автор), Vincenzo Canzonieri (Автор), Tiziano Tuccinardi (Автор), Antonio Giordano (Автор), Flavio Rizzolio (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Предметы: article
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PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumor...