A Guide to PIN1 Function and Mutations Across Cancers

• Main Authors: Maguie El Boustani (Author), Lucia De Stefano (Author), Isabella Caligiuri (Author), Nayla Mouawad (Author), Carlotta Granchi (Author), Vincenzo Canzonieri (Author), Tiziano Tuccinardi (Author), Antonio Giordano (Author), Flavio Rizzolio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumor...