Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial

• Main Authors: Gilmar Reis (Author), Eduardo Augusto dos Santos Moreira Silva (Author), Daniela Carla Medeiros Silva (Author), Lehana Thabane (Author), Aline Cruz Milagres (Author), Thiago Santiago Ferreira (Author), Castilho Vitor Quirino dos Santos (Author), Adhemar Dias de Figueiredo Neto (Author), Eduardo Diniz Callegari (Author), Leonardo Cançado Monteiro Savassi (Author), Maria Izabel Campos Simplicio (Author), Luciene Barra Ribeiro (Author), Rosemary Oliveira (Author), Ofir Harari (Author), Holly Bailey (Author), Jamie I Forrest (Author), Alla Glushchenko (Author), Sheila Sprague (Author), Paula McKay (Author), Craig R. Rayner (Author), Hinda Ruton (Author), Gordon H. Guyatt (Author), Edward J. Mills (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: Observational studies have postulated a therapeutic role of metformin in treating COVID-19. We conducted an adaptive platform clinical trial to determine whether metformin is an effective treatment for high-risk patients with early COVID-19 in an outpatient setting. Methods: The...