Evolution of the Transmission-Blocking Vaccine Candidates Pvs28 and Pvs25 in Plasmodium vivax: Geographic Differentiation and Evidence of Positive Selection.

• Main Authors: Ricardo A Chaurio (Author), M Andreína Pacheco (Author), Omar E Cornejo (Author), Ester Durrego (Author), Craig E Stanley (Author), Andreína I Castillo (Author), Sócrates Herrera (Author), Ananias A Escalante (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transmission-blocking (TB) vaccines are considered an important tool for malaria control and elimination. Among all the antigens characterized as TB vaccines against Plasmodium vivax, the ookinete surface proteins Pvs28 and Pvs25 are leading candidates. These proteins likely originated by a gene dup...