Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection

• Main Authors: Priscilla Aparecida Tartari Pereira (Author), Bruno Caetano Trindade (Author), Adriana Secatto (Author), Roberto Nicolete (Author), Camila Peres-Buzalaf (Author), Simone Gusmão Ramos (Author), Ruxana Sadikot (Author), Claudia da Silva Bitencourt (Author), Lúcia Helena Faccioli (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2013-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Prostaglandins act as mediators of inflammation and, similar to cytokines, function as immune modulators during innate and adaptive immune responses. Therefore, using a pharmacological inhibitor, celecoxib, we investigated the role of prostaglandins in host defense against Histoplasma capsulatum inf...