Reversal of Ovarian Cancer Cell Lines Multidrug Resistance Phenotype by the Association of Apiole with Chemotherapies

• Main Authors: Carolina Afonso de Lima (Author), Ian Lucas de Souza Bueno (Author), Stanley Nunes Siqueira Vasconcelos (Author), Juliana Mozer Sciani (Author), Ana Lúcia Tasca Gois Ruiz (Author), Mary Ann Foglio (Author), João Ernesto de Carvalho (Author), Giovanna Barbarini Longato (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR) is the main obstacle in anticancer therapy. The use of drug combinations to circumvent tumor resistance is a well-established principle in the clinic. Among the therapeutic targets, glycoprotein-P (P-gp), an energy-dependent transmembrane efflux pump responsible for modula...