A high molar activity 18F-labeled TAK-875 derivative for PET imaging of pancreatic β-cells

• Main Authors: Mark H. Dornan (Author), Daniil Petrenyov (Author), José-Mathieu Simard (Author), Antonio Aliaga (Author), Guoming Xiong (Author), Julien Ghislain (Author), Barry Bedell (Author), Vincent Poitout (Author), Jean N. DaSilva (Author)
• Format: Book
• Published: SpringerOpen, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The free-fatty acid receptor-1 (FFA-1) is expressed by β-cells and is a promising target for molecular imaging of functional β-cell mass. Recently, the ((3-[18F]fluoropropyl)sulfonyl)propoxy-derivative of the high-affinity FFA-1 agonist TAK-875 ([ 18 F]7) was reported. Here we de...