Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo

• Main Authors: Zhiqiang Zhang (Author), Xiaoran Guo (Author), Kenneth K.W. To (Author), Zhen Chen (Author), Xiaona Fang (Author), Min Luo (Author), Chunling Ma (Author), Jianhua Xu (Author), Shirong Yan (Author), Liwu Fu (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpressing of ATP-binding cassette (ABC) transporters is the essential cause of multidrug resistance (MDR), which is a significant hurdle to the success of chemotherapy in many cancers. Therefore, inhibiting the activity of ABC transporters may be a logical approach to circumvent MDR. Olmutinib...