A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

• Main Authors: Chao Wu (Author), Zhi-Hong Huang (Author), Zi-Qi Meng (Author), Xiao-Tian Fan (Author), Shan Lu (Author), Ying-Ying Tan (Author), Lei-Ming You (Author), Jia-Qi Huang (Author), Antony Stalin (Author), Pei-Zhi Ye (Author), Zhi-Shan Wu (Author), Jing-Yuan Zhang (Author), Xin-Kui Liu (Author), Wei Zhou (Author), Xiao-Meng Zhang (Author), Jia-Rui Wu (Author)
• Format: Book
• Published: BMC, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been totally elucidated. Methods Here, to...