Design, Synthesis, and Biological Evaluation of 4,4'-Difluorobenzhydrol Carbamates as Selective M₁ Antagonists

• Main Authors: Jonas Kilian (Author), Marius Ozenil (Author), Marlon Millard (Author), Dorka Fürtös (Author), Verena Maisetschläger (Author), Wolfgang Holzer (Author), Wolfgang Wadsak (Author), Marcus Hacker (Author), Thierry Langer (Author), Verena Pichler (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to their important role in mediating a broad range of physiological functions, muscarinic acetylcholine receptors (mAChRs) have been a promising target for therapeutic and diagnostic applications alike; however, the list of truly subtype-selective ligands is scarce. Within this work, we have ide...